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pentobarbital will lower the level or result of buprenorphine, prolonged-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Individuals who transfer to buprenorphine very long-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers need to be monitored to be certa